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Gene Info

Gene Information For:Hs. AKT1, v-akt murine thymoma viral oncogene homolog 1
Sequence ID:NM_001014431
NM_001014432
NM_005163
RefSeqGene ID:NG_012188
Entrez Gene ID:207
Ensembl ID:ENSG00000142208

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA, OVARIAN, SOMATICCDH1
CTNNB1
OPCML
PARK2
PIK3CA
PIK3CA
BREAST CANCERATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
BREAST-OVARIAN CANCER, FAMILIAL, 1BRCA1
MSH6
OPCML
PARK2
PIK3CA
PIK3CA
COLON CANCERAPC
APC
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
TP53
TP53
PROTEUS SYNDROME, SOMATICPTEN
SCHIZOAFFECTIVEDISORDERAPOL1
APOL2
APOL4
CHI3L1
CHI3L1
COMT
DAO
DAOA
DISC1
DISC2
DRD3
DTNBP1
HTR2A
LGR4
MTHFR
MTHFR
RTN4R
SYN2

Cytogenetic Location (from UniGene)

Cytogenetic Location:14q32.32Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 105236679 - 105258980

 Exon Info From UCSC:
NM_001014431
NM_001014432
NM_005163

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2964603Full LengthBC000479v-akt murine thymoma viral oncogene homolog 1
6645486Full LengthBC084538v-akt murine thymoma viral oncogene homolog 1
3354010IncompleteBC001737v-akt murine thymoma viral oncogene homolog 1
5212292IncompleteBC063408v-akt murine thymoma viral oncogene homolog 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001014432  NP_005154  NP_001014431  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001014431 NP_001014431 P31749 EC 2.7.11.1 Pkinase
PH
Pkinase_C
NM_001014432 NP_001014432 P31749 EC 2.7.11.1 Pkinase
PH
Pkinase_C
NM_005163 NP_005154 P31749 EC 2.7.11.1 Pkinase
PH
Pkinase_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M63167 AAA36539 P31749 EC 2.7.11.1
BC000479 AAH00479 P31749 EC 2.7.11.1
BC001737 AAH01737 Q9BV07  
BC084538 AAH84538 P31749 EC 2.7.11.1
EU832571 ACE86973    
EU832491 ACE87663    
AK314256 BAG36922 P31749 EC 2.7.11.1
AK122894 BAG53786 B3KVH4  
AB451242 BAG70056 P31749 EC 2.7.11.1
AB451367 BAG70181 P31749 EC 2.7.11.1
AK299310 BAH12997 B7Z5R1  
X61037 CAA43372 P31749 EC 2.7.11.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens AKT1 NP_001014431 M.musculus Akt1 11651 Gene Info NP_033782 98
R.norvegicus Akt1 24185   NP_150233 98
C.elegans akt-1 179424   NP_001023645 60
C.elegans akt-2 181524   NP_510357 56

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta