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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Sequence ID:NM_004985
NM_033360
RefSeqGene ID:NG_007524
Entrez Gene ID:3845
Ensembl ID:ENSG00000133703

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CASP8
CYP2A6
DLEC1
EGFR
ERBB2
ERCC6
FASLG
IRF1
MAP3K8
MAP3K8
PARK2
PIK3CA
PIK3CA
PPP2R1B
RASSF1
SLC22A18
BLADDER CANCER, SOMATICFGFR3
HRAS
LOC100270680
RB1
TACC3
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
CARDIOFACIOCUTANEOUS SYNDROMEBRAF
MAP2K1
MAP2K2
CONGENITAL MYOPATHY WITH EXCESS OF MUSCLE SPINDLESHRAS
GASTRIC CANCER RISK AFTER H. PYLORI INFECTIONAPC
APC
CASP10
CDH1
ERBB2
FGFR2
IL1B
IL1RN
IRF1
KLF6
KLF6
MUTYH
PIK3CA
PIK3CA
NOONAN SYNDROME 3 
PANCREATIC CANCERBRCA2
MANF
PALLD
TP53
TP53
SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME, SOMATIC MOSAICHRAS

Cytogenetic Location (from UniGene)

Cytogenetic Location:12p12.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 25362728 - 25398318

 Exon Info From UCSC:
NM_004985
NM_033360

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3878884Full LengthBC013572v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
3450509IncompleteBC010502v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
5301134IncompleteBC029545v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_203524  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_004985 NP_004976    
NM_033360 NP_203524 P01116 Ras

Related Sequences

 
mRNAGenPeptSwissProt
M35504 AAA35689 Q14014
M35505 AAA35690 Q14015
M17087 AAA36555 Q15285
M54968 AAB41942 P01116
BC013572 AAH13572 P01116
AF493917 AAM12631 P01116
BT007153 AAP35817 P01116
DQ890649 ABM81575  
DQ893829 ABM84755  
AK292510 BAF85199 P01116

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens KRAS NP_004976 R.norvegicus Kras 24525   NP_113703 97
M.musculus Kras 16653 Gene Info NP_067259 97
A.gambiae AgaP_AGAP002219 1269341   XP_307965 81
D.melanogaster Ras85D 41140   NP_476699 80
C.elegans let-60 178104   NP_502213 79
S.cerevisiae RAS1 854268   NP_014744 64
S.cerevisiae RAS2 855625   NP_014301 59

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta