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Gene Info

Gene Information For:Hs. PTEN, Phosphatase and tensin homolog
Sequence ID:NM_000314
RefSeqGene ID:NG_007466
Entrez Gene ID:5728
Ensembl ID:ENSG00000171862

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
BANNAYAN-RILEY-RUVALCABA SYNDROME 
COWDEN DISEASEBMPR1A
ENDOMETRIAL CANCERCDH1
MLH3
MSH6
GLIOBLASTOMABRCA2
DMBT1
ERBB2
LGI1
MSH2
PPARG
WDR11
GLIOMA SUSCEPTIBILITY 2 
JUVENILE POLYPOSIS SYNDROME, INFANTILE FORMBMPR1A
SMAD4
MACROCEPHALY/AUTISM SYNDROME 
MALIGNANT MELANOMA, SOMATICMC1R
MENINGIOMAMN1
NF2
SUFU
PROSTATE CANCERAR
BRCA2
CD82
CDH1
CHEK2
CHEK2
ELAC2
HIP1
HIP1
HNF1B
KLF6
KLF6
MAD1L1
MSR1
MXI1
MXI1
TUSC3
TUSC3
ZFHX3
PROTEUS SYNDROME, SOMATICAKT1
SQUAMOUS CELL CARCINOMA, HEAD AND NECKING1
ING1
TNFRSF10B
THYROID CARCINOMA, FOLLICULARHRAS
MINPP1
NRAS
VATER MACROCEPHALY AND VENTRICULOMEGALY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q23.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 89726449 - 89728532

NM_000314 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
16668962319489623859
66711108962386189624304
111111958965378189653865
119612408968526989685313
124112848969080289690845
128515238969276989693007
152416658971187489712015
166618328971760989717775
183320578972065089720874
205855458972504389728530

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3937787Full LengthBC005821phosphatase and tensin homolog

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000305  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000314 NP_000305 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
DSPc

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U96180 AAB66902 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
U92436 AAC51182 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
U93051 AAC51183 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
BC005821 AAH05821 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
DQ892604 ABM83530    
DQ895562 ABM86488    
EU176713 ABW03514    
JF268690 ADZ48535 F2YHV0  
AK313581 BAG36351 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48
CR450306 CAG29302 P60484 EC 3.1.3.67
EC 3.1.3.16
EC 3.1.3.48

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PTEN NP_000305 R.norvegicus Pten 50557   NP_113794 100
M.musculus Pten 19211 Gene Info NP_032986 100
A.gambiae AgaP_AGAP009628 3292014   XP_553421 51
D.melanogaster Pten 43991   NP_599149 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta