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Gene Info

Gene Information For:Hs. SMPD1, Sphingomyelin phosphodiesterase 1, acid lysosomal
Sequence ID:NM_000543
NM_001007593
RefSeqGene ID:NG_011780
Entrez Gene ID:6609
Ensembl ID:ENSG00000166311

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
NIEMANN-PICK DISEASE, TYPE A 
NIEMANN-PICK DISEASE, TYPEB 

Cytogenetic Location (from UniGene)

Cytogenetic Location:11p15.4-p15.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 6411660 - 6416225

 Exon Info From UCSC:
NM_000543
NM_001007593

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5762229Full LengthBC041164sphingomyelin phosphodiesterase 1, acid lysosomal

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000534  NP_001007594  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000543 NP_000534   Metallophos
NM_001007593 NP_001007594   Metallophos

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M59916 AAA58377 P17405 EC 3.1.4.12
BC041164 AAH41164 Q8IUN0  
AY649987 AAV68198    
HQ132745 ADW08999 E9LUE6  
HQ132746 ADW09000 E9LUE7  
HQ132747 ADW09001 E9LUE8  
HQ132748 ADW09002 E9LUE9  
AB209775 BAD93012 Q59EN6  
AK292388 BAF85077 A8K8M3  
X52678 CAA36901 P17405 EC 3.1.4.12
X52679 CAA36902 P17405 EC 3.1.4.12
X59960 CAA42584 P17405 EC 3.1.4.12

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SMPD1 NP_001007594 R.norvegicus Smpd1 308909   NP_001006998 83
M.musculus Smpd1 20597 Gene Info NP_035551 83
A.gambiae AgaP_AGAP011940 1280729   XP_320591 45
D.melanogaster CG3376 37884   NP_726435 44
C.elegans asm-2 181323   NP_509894 41
C.elegans asm-3 176879   NP_001040996 38
C.elegans asm-1 174131   NP_495415 36

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta