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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. EGFR, epidermal growth factor receptor
Sequence ID:NM_005228
NM_201282
NM_201283
NM_201284
RefSeqGene ID:NG_007726
Entrez Gene ID:1956
Ensembl ID:ENSG00000146648

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CASP8
CYP2A6
DLEC1
ERBB2
ERCC6
FASLG
IRF1
KRAS
MAP3K8
MAP3K8
PARK2
PIK3CA
PIK3CA
PPP2R1B
RASSF1
SLC22A18

Cytogenetic Location (from UniGene)

Cytogenetic Location:7p12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:7: 55086824 - 55273582

 Exon Info From UCSC:
NM_005228
NM_201282
NM_201283
NM_201284

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
30528231Full LengthBC094761epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
40117840IncompleteBC128419epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_958440  NP_005219  NP_958441  NP_958439  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_005228 NP_005219 P00533 EC 2.7.10.1 Furin-like
Recep_L_domain
Pkinase_Tyr
NM_201282 NP_958439     Furin-like
Recep_L_domain
NM_201283 NP_958440     Furin-like
Recep_L_domain
NM_201284 NP_958441     Furin-like
Recep_L_domain

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
K03193 AAA52371    
U95089 AAB53063 P00533 EC 2.7.10.1
U48722 AAC50802 P00533 EC 2.7.10.1
AF125253 AAG43240 P00533 EC 2.7.10.1
BC094761 AAH94761 Q504U8  
BC118665 AAI18666 Q147T7  
BC128419 AAI28420 A2VCQ7  
AF277897 AAK01080 P00533 EC 2.7.10.1
AY550966 AAT52212 Q2TTR7  
AY698023 AAT97978 Q68GS6  
AY698024 AAT97979 P00533 EC 2.7.10.1
DQ088980 AAZ66620 A9CB80  
EF210210 ABQ66237 B6RC65  
EF210211 ABQ66238 B6RC66  
GU255993 ADL28125 E7BSV0  
HM437234 ADN43066 E2I6F5  
HQ999997 ADY76965 F1JTL6  
HQ912715 ADZ75461 F2YGG7  
AB209442 BAD92679 Q59FL8  
AK290352 BAF83041 A8K2T7  
AK294750 BAH11869 B7Z2I3  
X00588 CAA25240 P00533 EC 2.7.10.1
X00663 CAA25282 P00533 EC 2.7.10.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens EGFR NP_005219 R.norvegicus Egfr 24329   NP_113695 91
M.musculus Egfr 13649 Gene Info NP_997538 91

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta