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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. SDHB, Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Sequence ID:NM_003000
RefSeqGene ID:NG_012340
Entrez Gene ID:6390
Ensembl ID:ENSG00000117118

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, stem cell, stomach, t-cell, testis, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
COWDEN-LIKE SYNDROMESDHD
GASTROINTESTINAL STROMAL TUMORKIT
PDGFRA
SDHC
PARAGANGLIOMA AND GASTRIC STROMAL SARCOMASDHC
SDHD
PARAGANGLIOMAS 4 
PHEOCHROMOCYTOMAGDNF
KIF1B
MAX
RET
SDHD
TMEM127
TMEM127
VHL

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p36.1-p35Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 17345375 - 17380527

NM_003000 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
192451734522617345452
2463681734910217349224
3694701735046717350568
4715871735424317354359
5887241735509417355230
7258101735955417359639
8119381737125517371382
93911611738044217380664

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4124737Full LengthBC007840succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_003000 NP_002991 P21912 EC 1.3.5.1  

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M32246 AAA35708 P21912 EC 1.3.5.1
U17248 AAA81167 P21912 EC 1.3.5.1
BC007840 AAH07840 P21912 EC 1.3.5.1
DQ403007 ABD77140 Q0QEY7  
D10245 BAA01089 P21912 EC 1.3.5.1
AK312056 BAG34992 P21912 EC 1.3.5.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SDHB NP_002991 M.musculus Sdhb 67680 Gene Info NP_075863 92
R.norvegicus Sdhb 298596   NP_001094009 92
S.cerevisiae SDH2 850685   NP_013059 73
A.gambiae AgaP_AGAP007309 1269860   XP_308512 71
D.melanogaster SdhB 35590   NP_477101 70
S.pombe sdh2 2542842   NP_593530 70
N.crassa NCU00959 3881320   XP_965152 67
C.elegans sdhb-1 174482   NP_495992 64
A.thaliana SDH2-3 836640   NP_680465 62

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta