Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools

Gene Info

Gene Information For:Hs. MSH6, mutS homolog 6 (E. coli)
Sequence ID:NM_000179
RefSeqGene ID:NG_007111
Entrez Gene ID:2956
Ensembl ID:ENSG00000116062

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
BREAST-OVARIAN CANCER, FAMILIAL, 1AKT1
BRCA1
OPCML
PARK2
PIK3CA
PIK3CA
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5 
ENDOMETRIAL CANCERCDH1
MLH3
PTEN
MISMATCH REPAIR CANCER SYNDROMEAPC
APC
MLH1
MSH2
PMS2

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p16Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 48026431 - 48034091

NM_000179 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
14124801022048010631
4136094801806548018261
6107794802303248023201
78033244802574948028293
332535904803055848030823
359137084803204848032165
370937984803275648032845
379939534803334248033496
395441534803359048033789
415443204803391748034083

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3629489Full LengthBC004246mutS homolog 6 (E. coli)
4374146IncompleteBC071594mutS homolog 6 (E. coli)
6498529IncompleteBC104665mutS homolog 6 (E. coli)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000170  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000179 NP_000170 P52701 MutS_V
PWWP
MutS_I
MutS_II
MutS_IV
MutS_III

Related Sequences

 
mRNAGenPeptSwissProt
U54777 AAB39212 P52701
U28946 AAC50461 P52701
BC004246 AAH04246 P52701
BC104665 AAI04666 Q3SWU9
DQ892898 ABM83824  
D89646 BAA23675 P52701
AK293921 BAG57302 B4DF41
AK304735 BAG65496 B4E3I4
Y16676 CAC79990 Q6LAI4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MSH6 NP_000170 R.norvegicus LOC100360342 100360342   XP_002729643 87
M.musculus Msh6 17688 Gene Info NP_034960 86
A.gambiae AgaP_AGAP003190 1273861   XP_312887 47
D.melanogaster Msh6 39654   NP_648755 44
A.thaliana MSH6 828147   NP_192116 40
C.elegans msh-6 171914   NP_491163 40
N.crassa NCU08135 3875816   XP_959678 37
S.cerevisiae MSH6 851671   NP_010382 36
S.pombe msh6 2539215   NP_588344 34

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)