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Gene Info

Gene Information For:Hs. TP53, tumor protein p53
Sequence ID:NM_000546
NM_001126112
NM_001126113
NM_001126114
NM_001126115
NM_001126116
NM_001126117
NM_001126118
RefSeqGene ID:NG_017013
Entrez Gene ID:7157
Ensembl ID:ENSG00000141510

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ADRENAL CORTICAL CARCINOMA 
BASAL CELL CARCINOMA 7 
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TSG101
XRCC3
XRCC3
CHOROID PLEXUS PAPILLOMA 
COLON CANCERAKT1
APC
APC
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
HEPATOBLASTOMA, SOMATICAPC
APC
AXIN1
CASP8
CTNNB1
MET
PDGFRL
PIK3CA
PIK3CA
LI-FRAUMENI SYNDROMECDKN2A
NASOPHARYNGEAL CARCINOMA 
OSTEOSARCOMACHEK2
CHEK2
RB1
TNFRSF11A
TNFRSF11A
PANCREATIC CANCERBRCA2
KRAS
MANF
PALLD

Cytogenetic Location (from UniGene)

Cytogenetic Location:17p13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 7571738 - 7590732

 Exon Info From UCSC:
NM_000546
NM_001126112
NM_001126113
NM_001126114
NM_001126115
NM_001126116
NM_001126117

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3544714Full LengthBC003596tumor protein p53

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000537  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000546 NP_000537 P04637 P53
P53_tetramer
P53_TAD
NM_001126112 NP_001119584    
NM_001126113 NP_001119585    
NM_001126114 NP_001119586    
NM_001126115 NP_001119587    
NM_001126116 NP_001119588    
NM_001126117 NP_001119589    
NM_001126118 NP_001119590    

Related Sequences

 
mRNAGenPeptSwissProt
M14694 AAA61211 P04637
M14695 AAA61212 P04637
AF307851 AAG28785 P04637
BC003596 AAH03596 P04637
AY429684 AAR10356 P04637
AY627884 AAT40418 Q6IT77
BT019622 AAV38428 Q5U0E4
DQ186648 ABA29753 P04637
DQ186649 ABA29754 P04637
DQ186650 ABA29755 P04637
DQ186651 ABA29756 P04637
DQ186652 ABA29757 P04637
DQ263704 ABB72446 Q2XSC7
DQ191317 ABB80262 P04637
DQ286964 ABB80266 P04637
DQ401704 ABD62752 Q27HK5
DQ485152 ABF61800 Q19RW5
DQ648884 ABG49480 Q0ZAK1
DQ648885 ABG49481 Q0ZAK0
DQ648887 ABG49482 Q0ZAJ9
EF101867 ABL09846 Q1MSX0
EF101868 ABL09847 Q1MSW8
EF101869 ABL09848 Q1MSW9
DQ892492 ABM83418  
DQ895704 ABM86630  
FJ207420 ACI25593 B6E4X6
JN900492 AEX20383 H2EHT1
JN601513 AEY81366 H6U5S2
JN601514 AEY81367 H6U5S3
JN601515 AEY81368 H6U5S4
JN601516 AEY81369 H6U5S5
AB082923 BAC16799 P04637
AK223026 BAD96746 Q53GA5
AK312568 BAG35463 P04637
AK297462 BAG59884 B4DMH2
AK297927 BAG60244 B4DNI2
AK303277 BAG64357 B4E095
X01405 CAA25652 P04637
X02469 CAA26306 P04637
X60010 CAA42625  
X60011 CAA42626 P04637
X60012 CAA42627 P04637
X60013 CAA42628 P04637
X60014 CAA42629 P04637
X60015 CAA42630 P04637
X60016 CAA42631 P04637
X60017 CAA42632 P04637
X60018 CAA42633 P04637
X60019 CAA42634 P04637
X60020 CAA42635 P04637
AM076970 CAJ28922 Q1MSX0
AM076972 CAJ28923 Q1MSW8
AM076971 CAJ28924 Q1MSW9

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TP53 NP_001119584 M.musculus Trp53 22059 Gene Info NP_035770 79
R.norvegicus Tp53 24842   NP_112251 79

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta