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Gene Info

Gene Information For:Hs. APP, Amyloid beta (A4) precursor protein
Sequence ID:NM_000484
NM_001204301
NM_201413
NM_001136016
NM_001204302
NM_001136130
NM_201414
NM_001204303
NM_001136131
NM_001136129
RefSeqGene ID:NG_007376
Entrez Gene ID:351
Ensembl ID:ENSG00000142192

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ALZHEIMER DISEASEA2M
ACE
APBB2
BLMH
HFE
MPO
NOS3
PAXIP1
PLAU
SORL1
CEREBRAL AMYLOID ANGIOPATHY, DUTCH, ITALIAN, IOWA, FLEMISH, ARCTICVARIANTS 

Cytogenetic Location (from UniGene)

Cytogenetic Location:21q21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:21: 27264075 - 27269935

 Exon Info From UCSC:
NM_000484
NM_201413
NM_001136130
NM_201414
NM_001136129

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6152423Full LengthBC065529amyloid beta (A4) precursor protein

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_958817  NP_958816  NP_000475  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000484 NP_000475 P05067 Kunitz_BPTI
A4_EXTRA
Beta-APP
NM_001136016 NP_001129488    
NM_001136129 NP_001129601    
NM_001136130 NP_001129602    
NM_001136131 NP_001129603    
NM_001204301 NP_001191230    
NM_001204302 NP_001191231    
NM_001204303 NP_001191232    
NM_201413 NP_958816   Kunitz_BPTI
A4_EXTRA
Beta-APP
NM_201414 NP_958817   A4_EXTRA
Beta-APP

Related Sequences

 
mRNAGenPeptSwissProt
M15533 AAA35540 P05067
M15532 AAA51564 P05067
M16765 AAA51722 P05067
M18734 AAA51726 P05067
M28373 AAA58727 P05067
M35675 AAA60163 P05067
S60721 AAB26263 P05067
S61380 AAB26264 P05067
S61383 AAB26265 P05067
BC004369 AAH04369 P05067
BC065529 AAH65529 P05067
AF282245 AAQ14327 P05067
EU832797 ACE87808  
GQ129348 ACT64482  
AB066441 BAB71958 P05067
AK312326 BAG35248 P05067
AK294534 BAG57741 B4DGD0
AK295621 BAG58500 B4DII8
AK296229 BAG58951 B4DJT9
AK297229 BAG59712 B4DM00
AK297412 BAG59847 B4DMD5
AK298861 BAG60983 B4DQM1
AK295373 BAH12049 B7Z313
A02759 CAA00268  
X06981 CAA30041 P05067
X06982 CAA30042 P05067
X06989 CAA30050 P05067
Y00264 CAA68374 P05067

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta