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Gene Info

Gene Information For:Hs. MAP3K8, mitogen-activated protein kinase kinase kinase 8
Sequence ID:NM_001244134
NM_005204
RefSeqGene ID:NG_029984
Entrez Gene ID:1326
Ensembl ID:ENSG00000107968

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CASP8
CYP2A6
DLEC1
EGFR
ERBB2
ERCC6
FASLG
IRF1
KRAS
PARK2
PIK3CA
PIK3CA
PPP2R1B
RASSF1
SLC22A18

Cytogenetic Location (from UniGene)

Cytogenetic Location:10p11.23Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 30723053 - 30749954

Transcript StartTranscript EndChromosomal Start Chromosomal End
14423072286530723306
4436733072610430726334
67410323072784430728202
103312003073671030736877
120114623073918630739447
146315693074056630740672
157017223074701230747164
172319693074818330748429
197030963074963430750760

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8143836Full LengthBC104833mitogen-activated protein kinase kinase kinase 8
8322618Full LengthBC113566mitogen-activated protein kinase kinase kinase 8

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005195  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001244134 NP_001231063      
NM_005204 NP_005195 P41279 EC 2.7.11.25 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC104833 AAI04834 P41279 EC 2.7.11.25
BC113566 AAI13567 P41279 EC 2.7.11.25
HQ258255 ADR83009    
D14497 BAA03387 P41279 EC 2.7.11.25
AB209539 BAD92776 Q59FC1  
AK290320 BAF83009 P41279 EC 2.7.11.25
AK313295 BAG36102 B2R8A5  
Z14138 CAA78512 P41279 EC 2.7.11.25
CR542284 CAG47079 Q6FG25  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MAP3K8 NP_005195 R.norvegicus Map3k8 116596   NP_446299 94
M.musculus Map3k8 26410 Gene Info NP_031772 93

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta