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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. DPYD, Dihydropyrimidine dehydrogenase
Sequence ID:NM_000110
NM_001160301
RefSeqGene ID:NG_008807
Entrez Gene ID:1806
Ensembl ID:ENSG00000188641

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
5-FLUOROURACIL TOXICITY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 97544531 - 98386478

 Exon Info From UCSC:
NM_000110
NM_001160301

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40123875Full LengthBC131777dihydropyrimidine dehydrogenase
40123878Full LengthBC131778dihydropyrimidine dehydrogenase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000101  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000110 NP_000101 Q12882 EC 1.3.1.2 Fer4
DHO_dh
Pyr_redox_2
NM_001160301 NP_001153773      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U09178 AAA57474 Q12882 EC 1.3.1.2
U20938 AAB51366 Q12882 EC 1.3.1.2
BC008379 AAH08379 Q96HL6  
BC064027 AAH64027 Q96HL6  
BC108742 AAI08743 Q32NB0  
BC131777 AAI31778 Q12882 EC 1.3.1.2
BC131778 AAI31779 Q12882 EC 1.3.1.2
BT006740 AAP35386 Q96HL6  
AB003063 BAA89789 Q12882 EC 1.3.1.2
AK291217 BAF83906 Q12882 EC 1.3.1.2
AK297515 BAG59923 B4DML1  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens DPYD NP_000101 M.musculus Dpyd 99586 Gene Info NP_740748 90
R.norvegicus Dpyd 81656   NP_112289 89
C.elegans dpyd-1 180818   NP_508927 67
D.melanogaster su(r) 31858   NP_572538 67
A.gambiae AgaP_AGAP001021 1270511   XP_309214 65
A.thaliana PYD1 821049   NP_188408 38

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)