Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools

Gene Info

Gene Information For:Hs. PARK2, Parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Sequence ID:NM_004562
NM_013987
NM_013988
RefSeqGene ID:NG_008289
Entrez Gene ID:5071
Ensembl ID:ENSG00000185345

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CASP8
CYP2A6
DLEC1
EGFR
ERBB2
ERCC6
FASLG
IRF1
KRAS
MAP3K8
MAP3K8
PIK3CA
PIK3CA
PPP2R1B
RASSF1
SLC22A18
ADENOCARCINOMA, OVARIAN, SOMATICAKT1
CDH1
CTNNB1
OPCML
PIK3CA
PIK3CA
BREAST-OVARIAN CANCER, FAMILIAL, 1AKT1
BRCA1
MSH6
OPCML
PIK3CA
PIK3CA
LEPROSYPACRG
PARKINSON DISEASE, JUVENILE, TYPE 2 

Cytogenetic Location (from UniGene)

Cytogenetic Location:6q25.2-q27Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:6: 161769670 - 163148800

 Exon Info From UCSC:
NM_004562
NM_013987
NM_013988

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4824892Full LengthBC022014Parkinson disease (autosomal recessive, juvenile) 2, parkin

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_054643  NP_004553  NP_054642  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_004562 NP_004553 O60260 ubiquitin
IBR
NM_013987 NP_054642   ubiquitin
IBR
NM_013988 NP_054643   ubiquitin
IBR

Related Sequences

 
mRNAGenPeptSwissProt
BC022014 AAH22014 O60260
AF381282 AAM21457 O60260
AF381283 AAM21458 O60260
AF381284 AAM21459 Q8NI42
AF381286 AAM21461 O60260
EF375726 ABN46990 O60260
GU345838 ADB90269 D3JZW5
GU345839 ADB90270 Q5VVX4
GU345840 ADB90271 D3JZW7
GU361466 ADB91978 D3JZW5
GU361467 ADB91979 D3K2X0
GU361468 ADB91980 D3K2X1
GU361469 ADB91981 D3K2X2
HQ447316 ADQ31803  
AB009973 BAA25751 O60260
AB245403 BAF43729 A1IGZ9
AK292590 BAF85279 O60260
AK294684 BAG57845 B4DGN4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PARK2 NP_004553 R.norvegicus Park2 56816   NP_064478 86
M.musculus Park2 50873 Gene Info NP_057903 84
A.gambiae AgaP_AGAP006580 1277163   XP_316606 47
D.melanogaster park 40336   NP_730601 46
C.elegans pdr-1 176816   NP_499846 37

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database